October 21, 2017

ORGANIC CHEMISTRY- I (NATURE OF BONDING AND STEREOCHEMISTRY)- TAUTOMERISM


ORGANIC CHEMISTRY- I (NATURE OF BONDING AND STEREOCHEMISTRY)- TAUTOMERISM

**Tautomers are isomers of a compound, which differ only in the position of the protons and electrons. The carbon skeleton of the compound is unchanged but functional groups are different's. 

**The alpha - hydrogen of carbony1 compounds is acidic, as it is connected with the alpha - carbon that is directly bound to the electron withdrawing carbony1 group. This is the main reason for the tautomerism to occur. 

**The acidifies of these alpha-hydrogen atoms is enhanced if an electron withdrawing group is attached to the alpha -carbon atom. 

**The establishment of equilibrium may be catalyzed by both acids and bases. Through suitable means, such as by fractional crystallization or careful distillation in the absence of any acid and any base, the keto and the enolic form may be separated from each other.

** It is generally difficult to say which is the labile form, since very often a slight change in the conditions, e.g., temperature, solvent, shifts the equilibrium from keto to enol or vice versa. 

**Many scientists have suggested various forms and theories of tautomerism and this module discusses an exhaustive list of some different types of tautomerism.




 
ORGANIC CHEMISTRY- I (NATURE OF BONDING AND STEREOCHEMISTRY)- TAUTOMERISM