**Cyclodextrins first discovered by French scientist named A. Villiers, are known as structurally related group of naturally occurring products formed during bacterial digestion of cellulose.
** The glucopyranose having the chair conformation is the reason cyclodextrins have a truncated cone shape rather than perfect cylindrical shape.
** The physical state of all three cyclodextrins is crystalline and they exist as white powder. CDs donot have a sharp melting point, however they begin to decompose from temperatures 200 °C and above.
** Pharmaceutically important cyclodextrin derivatives encompass the hydroxypropy1 derivatives of beta and y-cyclodextrin. the randomly methylated Beta-cyclodextrin, sulfobutylether Beta-cyclodextrin, and the branched cyclodextrins such as glucosy1- Beta -
*** cyclodextrin.
** The most intriguing property of cyclodextrins is these molecules are able to form solid inclusion complexes also known as host-guest complexes with a very large range of solid, liquíd and gaseous compounds by following a molecular complexation protocol.
** The most widely known pharmaceutical application of cyclodextrins is their ability to enhance the stability, solubility, bioavailability and safety of drug molecules.
** These characteristic properties of cyclodextrins or their derivatives make them appropriate for applications in analytical chemistry, the pharmaceutical industry, agriculture, in development of food flavours and toilet articles.
ORGANIC CHEMISTRY- I (NATURE OF BONDING AND STEREOCHEMISTRY)- CYCLODEXTRINS - 1
ORGANIC CHEMISTRY- I (NATURE OF BONDING AND STEREOCHEMISTRY)- CYCLODEXTRINS - 1